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. 2016 Mar 24;7(3):e2157. doi: 10.1038/cddis.2015.401

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Copyright © 2016 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Knockdown ARHGAP10 inhibited ovarian cancer cells proliferation in vitro and in vivo. (a) Expression of ARHGAP10 in five ovarian cancer cell lines as determined by western blotting. Left panel, representative results of western blot; right panel, protein levels relative to GAPDH. (b) Ectopic expression of ARHGAP10 in A2780 and HO-8910 cells was detected by western blotting. (c) Ectopic expression of ARHGAP10 significantly reduced cell proliferation as determined by CCK-8 assay. (d) A2780 cells stably infected with vector or ARHGAP10 virus were subcutaneously inoculated into nude mice (six per group). Overexpression of ARHGAP10 significantly inhibited tumor growth in nude mice xenograft model (**P<0.01, ***P<0.001)