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. 2016 Mar 24;7(3):e2157. doi: 10.1038/cddis.2015.401

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Copyright © 2016 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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ARHGAP10 functions through inhibiting Cdc42 activation. (a) Co-immunoprecipitation analysis showed that ARHGAP10 interacts with Cdc42 in A2780 cells. (b) Activation of Cdc42 was determined by GST-PBD pull-down assay. GST-PBD fusion protein was used as quantitative control, and total Cdc42 in protein lysates was shown. (c) Cdc42 expression was detected in A2780 cells transfected with Cdc42 siRNA or control siRNA (Mock) by western blotting. (d) Cdc42 knockdown significantly reduced cell proliferation as determined by CCK-8 assay. (e) Cdc42 knockdown induced cell arrest in G1 phase of cell cycle. (f) Cdc42 knockdown notably inhibited the adhesion, motility and invasiveness of A2780 cells (**P<0.01, ***P<0.001)