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. 2016 Mar 31;7(3):e2163. doi: 10.1038/cddis.2016.14

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Copyright © 2016 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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TGase 2 chaperones p53 to p62. (a and b) TGase 2 knockdown abolished the interaction of p53 to p62 as well as the interaction of TGase 2 to p53 and p62. TGM2 was silenced in ACHN (a) or CAKI-1 (b) cells for 48 h under starvation conditions, and then cell extracts were subjected to immunoprecipitation of TGase 2, p53, and p62. (c) TGase 2 activity is not required for interacting with p53. Wild-type or catalytically inactive TGase 2 (double mutant, C277S and C370A) was co-transfected with p62 into HEK293 cells. TGase 2 was immunoprecipitated using an anti-HA-tag antibody, followed by immunoblotting of TGase 2, p53 and p62