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. 2016 Mar 24;7(3):e2159. doi: 10.1038/cddis.2016.27

Figure 5.

Figure 5

Inhibition of spontaneous lung metastatic capabilities of breast cancer cells by miR-485-3p and miR-485-5p. (a) The expression levels of miR-485-3p or miR-485-5p in MDA-MB-231 cells transduced with LV-miR-control, LV-miR-485-3p or LV-miR-485-5p. (b) Representative photos of H&E staining of lung tissue sections from mice subjected to tail vein injection of MDA-MB-231 cells stably expressing miR-control (LV-miR-control), miR-485-3p (LV-miR-485-3p) or miR-485-5p (LV-miR-485-5p), and quantification of relative metastatic lung surface area. (c) The quantification of metastatic nodules in lungs from mice subjected to tail vein injection of MDA-MB-231 cells stably expressing miR-control (LV-miR-control), miR-485-3p (LV-miR-485-3p) or miR-485-5p (LV-miR-485-5p). Scale bars: 200 μm. **P<0.05, ***P<0.001 by one-way ANOVA compared with the LV-miR control group