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(a) The representative structures of bioactive tricyclic derivatives reported previously. (b) The P-gp expression in H460TaxR and H460 cells. (c and d) The dose-dependent cytotoxicity of PTX or TBPT. The cytotoxicity of PTX (c) or TBPT (d) were analyzed in NSCLC cell lines H460TaxR, H460 and normal fibroblasts cell line NHFB (N=3). The EC50 of compounds were shown in the corresponding colors of cell lines
