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. 2016 Mar 31;7(3):e2164. doi: 10.1038/cddis.2016.55

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Copyright © 2016 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Time course of cytotoxic, proliferating and IFNγ-producing T-cells. The kinetics of Granzyme (a and b) and Ki67 (c and d) expression on CD8 (black triangles) or CD4 (white squares) T-cells are analyzed by intracellular staining and flow cytometry. The kinetics of viral load is reported (gray dotted line). The Elispot images showing the IFN-γ production after PHA stimulation at different time point (T8, T34 and T120 for ot1 and T6, T17 for pt2) are reported (e and f)