Figure 5.

ARTD1^D214N causes high bone mass associated with decreased OC number. (a) Cross sections of 3 D μCT reconstruction of trabecular bones of distal femoral metaphyses, and (b) trabecular bone mass (BV/TV) from 2-week-old Artd1^+/+ and Artd1^D214N/D214N male mice. Scale bar, 250 μm. (c) Cross sections of 3 D μCT reconstruction of distal femoral metaphyses, and (d) BV/TV from 8-week-old Artd1^+/+ and Artd1^D214N/D214N male mice. Scale bar, 500 μm. (e) TRAP staining of bone sections; (i) and (ii) represent a higher view of the area highlighted by the red box. (f) Histomorphometric analysis of OC number/bone surface (Oc. N/BS) from WT and Artd1^D214N/D214N mice. (g) OC surface/bone surface (Oc.S/BS). Quantitative data are from 8 Artd1^+/+ mice and 5 Artd1^D214N/D214N mice (b), and 4 Artd1^+/+ mice and 4 Artd1^D214N/D214N mice (d, f and g). Data are expressed as mean±S.D. *P<0.05