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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: Atherosclerosis. 2015 Oct 31;244:93–100. doi: 10.1016/j.atherosclerosis.2015.10.106

Table 2.

DCCT baseline lipoprotein profiles vs. common carotid IMT at EDIC year 12 (Standardized linear regression coefficients)

Variables Men (n=244) Women (n=208)
Unadjusted Adjusted* Unadjusted Adjusted*
NMR subclasses Slope(SE) P Slope(SE) P Slope(SE) P Slope SE P
 Total VLDL and chylomicrons (nmol/L) 0.08 (0.06) 0.19 0.003 (0.06) 0.96 −0.03 (0.07) 0.71 −0.03 (0.08) 0.73
  Large VLDL & chylomicrons (nmol/L) 0.05 (0.06) 0.39 −0.06 (0.06) 0.37 0.03 (0.07) 0.69 0.01 (0.08) 0.89
  Medium VLDL (nmol/L) −0.01 (0.06) 0.88 −0.06 (0.06) 0.26 −0.03 (0.08) 0.75 −0.02 (0.09) 0.85
  Small VLDL (nmol/L) 0.11 (0.06) 0.09 0.05 (0.06) 0.43 −0.02 (0.07) 0.72 −0.03 (0.07) 0.72
 Total IDL/LDL (nmol/L) 0.27 (0.06) <0.0001 0.20 (0.06) 0.001 0.06 (0.07) 0.35 0.08 (0.07) 0.30
  IDL (nmol/L) 0.01 (0.07) 0.91 −0.04 (0.06) 0.51 0.05 (0.07) 0.49 0.05 (0.07) 0.51
  Large LDL (nmol/L) 0.17 (0.07) 0.009 0.16 (0.06) 0.01 0.0. (0.07) 0.67 0.04 (0.07) 0.59
  Small LDL (nmol/L) 0.13 (0.06) 0.03 0.07 (0.06) 0.22 0.03 (0.07) 0.73 0.03 (0.08) 0.73
 Total HDL (μmol/L) 0.01 (0.07) 0.89 −0.02 (0.07) 0.81 0.06 (0.06) 0.34 0.04 (0.06) 0.54
  Large HDL (μmol/L) −0.09 (0.07) 0.23 0.01 (0.07) 0.84 0.03 (0.07) 0.70 0.03 (0.07) 0.70
  Medium HDL (μmol/L) 0.02 (0.08) 0.83 −0.02 (0.07) 0.76 0.02 (0.06) 0.67 0.01 (0.06) 0.90
  Small HDL (μmol/L) 0.04 (0.07) 0.56 −0.005 (0.07) 0.94 0.02 (0.06) 0.70 0.02 (0.07) 0.73
NMR particle diameter
  VLDL particle size (nm) −0.02 (0.06) 0.75 −0.07 (0.06) 0.28 0.07 (0.07) 0.32 0.05 (0.07) 0.47
  LDL particle size (nm) −0.005 (0.06) 0.94 0.02 (0.06) 0.76 0.01 (0.08) 0.90 0.01 (0.08) 0.92
  HDL particle size (nm) −0.13 (0.07) 0.046 −0.05 (0.06) 0.44 0.04 (0.07) 0.60 0.05 (0.08) 0.54
Conventional lipids
  Total cholesterol (mg/dl) 0.18 (0.06) 0.0045 0.13 (0.06) 0.03 0.05 (0.07) 0.47 0.06 (0.07) 0.40
  Triglyceride (mg/dl) 0.14 (0.05) 0.01 0.05 (0.05) 0.32 −0.03 (0.09) 0.73 −0.06 (0.10) 0.54
  LDL cholesterol (mg/dl) 0.17 (0.06) 0.006 0.13 (0.16) 0.03 0.03 (0.07) 0.68 0.04 (0.07) 0.54
  Non-HDL cholesterol (mg/dl) 0.18 (0.06) 0.0025 0.12 (0.06) 0.04 0.02 (0.07) 0.78 0.03 (0.08) 0.68
  HDL cholesterol (mg/dl) −0.03 (0.08) 0.72 0.05 (0.07) 0.46 0.07 (0.06) 0.29 0.07 (0.07) 0.28
*

Models were adjusted for DCCT randomization, albumin excretion rate, HbA1C, diabetes duration, body mass index, and current smoking at DCCT baseline (1983–89). The regression models were also adjusted for statin use (any time during the DCCT baseline to EDIC year 12), ultrasound devices, and image readers at EDIC year 12.

P values in bold if significant (<0.05).