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Shc1 phosphopeptide binding to the EGFR kinase domain. (a) Overall structure of the EGFR L858R kinase domain bound to a Shc1 peptide phosphorylated at Tyr240 (PDHQYpYNDF). The peptide is shown in stick form. (b) Detailed view of interactions between EGFR and the primed Shc1 substrate peptide. Hydrogen bonds are indicated with dashed lines.
