Fig. 4.

Histologic (hematoxylin and eosin) effects of nimodipine microparticles in rats sacrificed 15 (top row) or 29 days (bottom row) after intraventricular injection of 0.9 % NaCl, placebo microparticles or nimodipine–poly(DL-lactide-co-glycolide) (PLGA) microparticles (0.33, 1, or 2 mg nimodipine). There was reactive gliosis, hydrocephalus, pigmented and foamy macrophages, focal mineralization, and vacuolation after injection of microparticles that was not related to dose. More intracranial hemorrhage was observed 15 days after injection of nimodipine–PLGA microparticles, 2 mg, that partly resolved by 29 days. Scale bar = 500 μm