Table 1.
Characteristics of 6 nimodipine–poly(DL-lactide-co-glycolide) formulations
| Number | Polymer composition (lactide:glycolide ratio, end group) | Theoretical drug content (weight %) | Actual drug content (weight %) | Encapsulation efficiency (%) | Main peak purity (%) | Particle size (μm) | Residual solvent (weight %) | Residual water (weight %) |
|---|---|---|---|---|---|---|---|---|
| 00447-098 | 65:35, ester | 65.0 | 62 ∀ 1.3 | 95.4 | 98.9 | 37.2 | 0.56 | 0.39 |
| 00447-102 | 65:35, acid | 65.0 | 61 ∀ 0.7 | 94.5 | 99.9 | 36.9 | 0.67 | 0.31 |
| 00447-104 | 75:25, acid | 65.0 | 56 ∀ 0.4 | 86.6 | 99.9 | 39.1 | 0.12 | 0.38 |
| 00447-106 | 75:25, acid | 65.0 | 63 ∀ 1.5 | 96.8 | 98.8 | 38.1 | 0.64 | 0.37 |
| 00447-108 | 50:50, acid | 65.0 | 64 ∀ 0.3 | 98 | 99.9 | 34.7 | 0.93 | 0.24 |
| 00447-110 | 65:35, ester | 50.0 | 49 ∀ 0.3 | 97.6 | 99.9 | 38.8 | 0.37 | 0.49 |
| 00447-116 | 65:35, ester | 66.5 | 61 ∀ 1.2 | 91.3 | 99.9 | 30.9 | 0.37 | 0.29 |
Data are means ± SD (n = 3 per measurement)