Table 2.
Characteristics and differential scanning calorimetry of 4 nimodipine–poly(DL-lactide-co-glycolide) formulations after storage for 30 days
| Number | Storage condition (°C) | Average drug content (weight %) | Encapsulation efficiency (%) | Particle size (μm) | Drug purity (%) | Tg (°C) | Main melt (°C) | Second melt (°C) |
|---|---|---|---|---|---|---|---|---|
| 00447-098 | 4 | 61.2 | 94.2 ∀ 4.7 | 74.5 | 99.5 | 34.1 | 126.1 | No peak |
| 00447-098 | 25 | 63.2 | 97.2 ∀ 2.9 | 77.8 | 99.6 | 42.1 | 126.5 | 113.8 (tiny peak) |
| 00447-098 | 30–35 | 66.2 | 101.8 ∀ 2.1 | 95.7 | 99.8 | 49 | 125.8 | 113.5 (tiny peak) |
| 00447-102 | 4 | 62.8 | 96.6 ∀ 3.3 | 63.5 | 99.4 | 34.6 | 125 | 114.2 (tiny peak) |
| 00447-102 | 25 | 57.6 | 88.6 ∀ 8.3 | 64.9 | 99.6 | 38 | 125 | 114.6 |
| 00447-102 | 30–35 | 65 | 100.1 ∀ 0.5 | 70.3 | 99.8 | 48.8 | 125 | 114.6 |
| 00447-108 | 4 | 63 | 96.9 ∀ 9.5 | 79.3 | 99.7 | 35 | 126.5 | No peak |
| 00447-108 | 25 | 62.8 | 96.6 ∀ 10.4 | 76.8 | 99.8 | 39.6 | 126.1 | No peak |
| 00447-108 | 30–35 | 68 | 104.6 ∀ 1.6 | 79.8 | 99.8 | 49.44 | 126.5 | No peak |
| 00447-110 | 4 | 52.1 | 104.3 ∀ 2.5 | 59.2 | 98.1 | 19.6 | 122 | 112.3 |
| 00447-110 | 25 | 45.5 | 91.0 ∀ | 127.4 | 99.7 | 33.9 | 112.7 | 122.4 |