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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: Bioorg Med Chem. 2015 Sep 25;23(21):6974–6992. doi: 10.1016/j.bmc.2015.09.036

Figure 5.

Figure 5

Representative progress curves of cathepsin L (1 nM) activity using Z-FR-AMC (10 μM) as substrate and increasing concentrations of (A) inhibitor 1 and (B) inhibitor 32 (0–10 μM). Reactions were initiated by the addition of enzyme with no pre-incubation with compounds. Release of the fluorescent product AMC was followed as a function of time.