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. Author manuscript; available in PMC: 2016 Apr 7.
Published in final edited form as: Science. 2013 Jan 11;339(6116):204–207. doi: 10.1126/science.1229326

Fig. 1. Ezh2 non-cell autonomous role in pontine neuron tangential migration.

Fig. 1

(A, B, E, F and G) Migratory phenotypes in control (A,B) and r5–6::Cre;Ezh2fl/fl mutants (E–G). Barhl1 in situ hybridization in E14.5 whole-mount (A,E), and E16.5 (B,F), E18.5 (G) sagittal sections. Pontine gray and reticulotegmental (arrowheads, G) nuclei (PN) are duplicated (PNe). (C and H) Tracings from P7 cortex (Rabies-ΔG-eGFP) and cerebellum (Rabies-ΔG-mCherry) in controls (C) and r5–6::Cre;Ezh2fl/fl mutants (H). Pontine (PN) and ectopic (PNe) nuclei are connected to cortex and cerebellum. (D, I, J and K) Barlh1/Netrin1 expression in E14.5 control (D), r5–6::Cre;Ezh2fl/fl (I), r5post::Cre;Ezh2fl/fl;Shhfl/+ (K), r5post::Cre;Ezh2fl/fl;Shhfl/fl (J) coronal sections. Ectopic Ntn1 (arrowheads,I,K) and PNe ectopic migration (arrows,I,K) are partially rescued (J).