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. Author manuscript; available in PMC: 2016 Apr 7.
Published in final edited form as: Science. 2013 Jan 11;339(6116):204–207. doi: 10.1126/science.1229326

Fig. 4. Pontine nuclei regionalization and patterned cortical input.

Fig. 4

(A, B, D, E and F), Hox expression summary in migrating pontine neurons of control (A) and r5–6::Cre;Ezh2fl/fl mutants (D). Barhl1/Hoxb5 in situ hybridization on E17.5 sagittal sections (B,E,F). In r5–6::Cre;Ezh2fl/fl mutants (E,F), Hoxb5+ neurons spread throughout the rostrocaudal extent of the ectopic nucleus (PNe) (arrowheads, F), while in PN they are normally posteriorly restricted as in control (arrowhead, B,E). (C and G) Rabies-ΔG viruses injected in control visual/medioposterior (MPC) and somatosensory (SSC) cortex anterogradely trace fibers into anterior (green,*) and posterior (red, arrow) PN (C), respectively. In r5–6::Cre;Ezh2fl/fl mutants (G), PNe lacks innervation by MPC, while is innervated by SSC (arrow). H, Ezh2- and Hox-dependent genetic circuitry of intrinsic and extrinsic Unc5b/Ntn1 regulation.