Table 4.
Macrophage defects in cell lines
| RAW 264.7 cells |
In Vitro |
||||
|---|---|---|---|---|---|
| Gene | Manipulation | Ca2+ signaling | Chemotaxis | Phagocytosis | Ref. No. |
| Stim1 | siStim1 | Decreased 70% (Tg) | Normal (C5a, CCL2) | Decreased 75% (opsonized RBC) | 109 |
| Stim2 | siStim2 | Decreased 30% (Tg). Decreased store content | Reduced 20% (C5a, CCL2) | Decreased 50% (opsonized RBC) | 109 |
The table lists the macrophage defects reported in the mouse monocyte/macrophage cell line RAW 264.7 (Abelson murine leukemia virus transformed) following silencing of Stim isoforms.