Figure 1.
The bacteriophage phi29 dsDNA packaging motor. A) Cut-away side view of the bacteriophage phi29 dsDNA packaging motor as determined by cryoEM. Molecular envelopes of the connector, pRNA, and ATPase are shown in green, magenta, and blue, respectively. B) Model of the mechano-chemical cycle of the packaging motor as determined by single molecule experiments (Chistol et al., 2012). The top and bottom halves of the panel show the chemical and mechanical transitions in the dwell phase and burst phases, respectively. Selected points of the mechano-chemical cycle that are specifically referred to in the text are marked by asterisks.