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Assessment of cytotoxicity of DOX modified compounds ND2DOX (with and without MMP9 treatment) and DOX-COOH compared to DOX. A: viability of 6 µM (in DOX) ND2DOX (triangle) and 12 µM (in DOX) cleaved ND2DOX (circle) compared to 5.5 µM DOX (square). B: viability of 152 µM DOX-COOH (triangle) comared to 11 µM DOX (rhombus).
