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. Author manuscript; available in PMC: 2016 Apr 7.
Published in final edited form as: J Proteome Res. 2012 Nov 30;12(1):481–490. doi: 10.1021/pr3009176

Figure 3.

Figure 3

Tracking metabolic profiles of survivors and nonsurvivors. Partial least-squares discriminant analysis (PLS-DA) of 1H NMR CSF metabolomic data comparing samples collected from rabies patients and controls (R2X = 0.34, R2Y = 0.87, Q2 = 0.81). Open circles represent control samples; black filled circles represent rabies patient samples. Red filled circles track a nonsurviving (NS) patient from hospital day 10 to day 18, as disease progresses this patient diverges further from control samples. The green filled circles track a survivor (S) who changes from a diseased metabolic profile to reflect a normal metabolic profile as the patient recovers from rabies disease. Hotelling’s T2 95% confidence ellipse is indicated on the plot.