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. Author manuscript; available in PMC: 2016 Apr 7.
Published in final edited form as: Int J Cancer. 2014 Oct 30;136(9):2055–2064. doi: 10.1002/ijc.29269

Figure 5.

Figure 5

Effect of combination of JQ1 and rapamycin on human OS xenografts in vivo. MNNG/HOS xenografts were grown in athymic nude mice and treated with JQ1 and/or rapamycin 72 hr after cell injection (Day 0). Ctrl, diluent control; JQ1, JQ1 (50 mg/kg body weight, i.p. daily); Rapa, rapamycin (1.5 mg/kg, i.p. every other day). (a) Volumetric growth of MNNG/HOS xenografts. Data show mean tumor volume ± standard deviation (SD, error bars) of five mice per group. (b) Comparison of tumor weight of each group. At Day 24, mice were sacrificed and tumors were dissected and weighed. Data represent mean tumor weight ± SD of ten tumors per group. Asterisks (*) indicate p-value less than 0.05 (*) or 0.001 (**) by t-test. (c) H&E staining show representative tumor sections of each group. Arrows indicate the boundaries of necrotic tumor cells in the combination group. Magnification ×200. NS: not significant.