Table 4.

Detection and False-Positive Rate for Standard Screening Policies and With Risk Modified by Genetic Sonogram Result

Policy*	Standard		After Sonogram
	Detection Rate	False-Positive Rate	Detection Rate	False-Positive Rate
Combined	88	8.7	95†	6.2†
Quadruple	86	12	93	7.4
Integrated	93	7.1	98	5.2
Stepwise	97	7.2	98	5.6
Contingent	95	6.6	97	5.0
Stepwise sonogram‡	—	—	95	6.2
Contingent sonogram‡	—	—	93	5.8

Data are %.

^*Cutoff based on midtrimester risk: 1 in 270 for final results, 1 in 30 and 1 in 1,500 for the first-stage high and low cutoffs in contingent and stepwise policies.

^†Not interpreting the test until the sonogram is complete.

^‡Replacing the second-stage quadruple markers with the sonogram.