Table 4.
Metabolic data over time for the Female-to-Male patient population.
| Parameter | Baseline | Visit 1 (3-6 months) |
Visit 2 (6-18 months) |
|---|---|---|---|
| N | 19 | 16 | 10 |
| BMI (kg/m2) | 28.1 ± 2.1 | 30.1 ± 2.3* | 25.2 ± 2.1 |
| sBP (mmHg) | 124 ± 4 | 133 ± 6 | 122 ± 5 |
| dBP (mmHg) | 76 ± 2 | 77 ± 2 | 75 ± 4 |
| TC (mg/dL) | 162 ± 6 | 160 ± 8 | 168 ± 19 |
| HDL (mg/dL) | 54 ± 4 | 48 ± 3 | 48 ± 8 |
| LDL (mg/dL) | 89 ± 6 | 94 ± 7 | 102 ± 15 |
| TG (mg/dL) | 96 ± 16 | 87 ± 11 | 83 ± 17 |
| Creat (mg/dL) | 0.73 ± 0.03 | 0.87 ± 0.04* | 0.82 ± 0.04** |
| Ca (mg/dL) | 9.3 ± 0.1 | 9.3 ± 0.1 | 9.6 ± 0.2 |
| ALT (U/L) | 23 ± 3 | 19 ± 2 | 16 ± 1 |
| AST (U/L) | 29 ± 9 | 23 ± 3 | 22 ± 3 |
| Hgb (g/dL) | 13.4 ± 0.3 | 14.2 ± 0.4* | 15.2 ± 0.4** |
| Hct (%) | 39.8 ± 0.8 | 43.4 ± 1.1** | 45.9 ± 1.2** |
| RBC (1x1012/L) | 4.51 ± 0.10 | 4.89 ± 0.12* | 5.12 ± 0.17* |
|
Average Daily
Testosterone dose |
0 | 10.71 mg/day | 11.36 mg/day |
*
signifies p < 0.05, using a paired t-test compared to baseline visit.
**
signifies p < 0.01 using a paired t-test compared to baseline visit.
N = sample size; BMI = body mass index; sBP = systolic blood pressure; dBP = diastolic blood pressure; TC = total cholesterol; HDL = high-density lipoprotein; LDL = low-density lipoprotein; TG = triglycerides; K = potassium; Creat = creatinine; Ca = calcium; ALT = alanine transaminase; and AST = aspartate transaminase. Hgb = hemoglobin; Hct = hematocrit; and RBC = red blood cell count. Data shown is average ± SEM