Table 1.

Ocular conditions leading to limbal stem cell deficiency

Traumatic, iatrogenic, and malignant causes: more favorable	Inflammatory, hereditary, and neuropathic causes: unfavorable
• Chemical or thermal burn	• Stevens–Johnson syndrome
• Multiple surgeries	• Mucous membrane pemphigoid
• Radiation	• Chronic limbitis
• Antimetabolites	• Chronic bullous keratopathy
• Contact lens wear	• Neurotrophic keratopathy: trigeminal neuralgia, diabetes, herpes simplex, and zoster
• Infections	• Aniridia
• Neoplasia	• Epidermal dysplasia