Table 2.
Risk factors for third-line PFS
| Variables | P-value | HR | 95% CI for HR
|
|
|---|---|---|---|---|
| Lower | Upper | |||
| Hgb | 0.037 | 3.249 | 1.072 | 9.853 |
| LDH | 0.301 | 1.000 | 1.000 | 1.001 |
| Na | 0.075 | 0.342 | 0.105 | 1.116 |
| Groupa | 0.923 | 1.071 | 0.266 | 4.313 |
| Cranial metastases | 0.337 | 1.850 | 0.527 | 6.493 |
| Bone metastases | 0.058 | 2.571 | 0.970 | 6.817 |
Notes:
a
Irinotecan followed by topotecan or topotecan followed by irinotecan. P-value: hazard regression model.
Abbreviations: Hgb, hemoglobin; LDH, lactate dehydrogenase; HR, hazard ratio; CI, confidential interval; PFS, progression-free survival; Na, sodium.