Fig 1. Baroreceptor reflex sensitivity for heart rate (HR).
(A) Linear regression graph showing: depressor response—the reflexive increase in heart rate (ΔHR) to decrease the mean arterial pressure (ΔMAP) produced by acute administration of sodium nitroprusside (7, 17, and 20 μg/kg); and pressor response—HR decrease reflex response to increase MAP produced by acute administration of phenylephrine (3, 6, and 10 μg/kg) in the control and bile duction ligation (BDL) groups. n, number of rats. *P < 0.05 compared to control group (Sutdent’t test). (B) Representative recording of cardiovascular responses induced by acute infusion of phenylephrine (Phe) and sodium nitroprusside (SNP) in the control and BDL groups. Pulse pressure (PP), heart rate (HR), beats per minute (bpm) and mean arterial pressure (MAP).