Figure 2.

Rejection of corneal grafts placed into HSV-1–infected low-risk hosts. (a) Wild-type BALB/c mice were infected with HSV-1 and corneal grafts were performed 10 dpi (grafts secured with continuous suture) when corneas typically do not have corneal neovascularization or corneal scar. (b, c) CD4^−/− BALB/c mice were infected with HSV-1 for 10 days prior to placement of corneal allografts (grafts secured with interrupted sutures; [b] C57BL/6J donors) or syngrafts (grafts secured with interrupted sutures; [c] WT BALB/c donors). Mice received 2 × 10⁶ naïve WT BALB/c CD4 T cells intravenously (with CD4s) at the time of transplant or not (no CD4s), and grafts were monitored for rejection at various times post transplant.