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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Biomaterials. 2016 Mar 17;91:140–150. doi: 10.1016/j.biomaterials.2016.03.023

Figure 3. G114 released by G114 MP-loaded MSCs is effective in preferentially killing PSA-secreting PCa cells.

Figure 3

(a) PSA secretion by LNCaP PCa cells and MDA-MB-231 breast cancer cells (5×104 MSCs in 24h). (b) Following incubation of MSCs (5×104 cells) with G114 MPs (0.1mg/mL, 16hours), media was replaced, collected after 72h and then applied on LNCaP PCa cells and MDA-MB-231 breast cancer cells for 72h. Cancer cell viability was then tested via XTT (n.s – LNCaP vs. MDA-MB statistically insignificant. *p<0.05 supernatant from G114-MP MSC treatment statistically significant vs. other indicated treatments, one-way ANOVA using Tukey’s HSD, error bars represent SD). (c) MP-loaded MSCs (5×104 cells) were co-cultured in a transwell system (0.4μm) in the presence of LNCaP or MDA-MB-231 cells (5×104 cells) for 72h, followed by XTT analysis to assess cancer cell viability (n.s – LNCaP vs MDA-MB statistically insignificant. *p<0.05 co-culture with G114-MP MSCs statistically significant vs. other indicated groups, one-way ANOVA using Tukey’s HSD, error bars represent SD).