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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: J Immunol. 2016 Mar 2;196(7):3079–3087. doi: 10.4049/jimmunol.1502061

Fig. 2. HBs is the major humoral immune tolerogen in the CHB model.

Fig. 2

Serum levels of HBs (A) and ayw subtype-specific anti-HBs antibody (B) in AAV/HBV carrier mice (n=3) were monitored by ELISA after vaccination with EnxB (2 µg) plus CpG (30 µg). (C) Spontaneous antibody responses to viral core antigen (n=10) and surface antigen (n=16) were monitored by ELISA at 4 and 8 weeks post infection. (D) Antibody responses to HBV surface antigen as well as HSV-1 gD antigen (n=3) were tested in AAV/HBV carrier mice and control mice infected with HSV-1 (5 × 107 pfu) and vaccinated with EnxB (2 µg). Control, C57BL/6j mice that were not infected with AAV/HBV. The data presented are representative of at least two independent experiments.