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. Author manuscript; available in PMC: 2016 May 5.
Published in final edited form as: Nature. 2015 Oct 28;527(7576):105–109. doi: 10.1038/nature15548

Extended Data Figure 2. LC3 interacts with LADs on chromatin.

Extended Data Figure 2

a, b, ChIP-qPCR of proliferating IMR90. c, ChIP-qPCR of LC3 knockdown IMR90. Bars are the mean ± s.e.m (a, b), s.d. (c); n=3; * P < 0.05, ** P < 0.005, *** P < 0.0001; n.s., non-significant; unpaired two-tailed Student’s t-test. d–i, ChIP-sequencing analyses. d, related to Fig. 2c, a zoom-in window of chromosome 3. e, f, Analyses of two replicates at LADs and LC3ADs. g, Per-nucleotide overlap of published datasets with the LADs called from this study. Number unit: megabase. h, Enrichment over LC3ADs. * P < 2.2×10−16; one-sided Wilcoxon test. i, Analysis of our Lamin B1 and LC3 ChIP-seq at LADs defined by other studies, and randomly sampled non-LADs loci (Ctrl). * P < 2.2×10−16; one-sided Wilcoxon test.