. 2016 Apr 7;11(4):e0153005. doi: 10.1371/journal.pone.0153005

Table 1. The Effects of DYN 1–17 and Its N-terminal Biotransformation Fragments on LPS-stimulated NF-κB/p65 nuclear translocation.

Treatment	Inhibition of NF-κB/p65 nuclear translocation		Modulation of IL-1β release			Modulation of TNF-α release
	10 nM	1 μM	10 pM	1 nM	0.1 μM	10 pM	1 nM	0.1 μM
DYN 1–17	√^*	√	↓	↓	↓^*	↔	↔	↔
DYN 1–6	√^*	√	↑	↑^*	↑	↔	↑	↑^*
DYN 1–7	√^*	X	↓^*	↓	↓	↓^*	↓^*	↓
DYN 1–9	√^*	√	↔	↔	↔	↔	↔	↔
DYN 1–10	√	√	↔	↔	↔	↔	↔	↔
DYN 1–11	√	√	↔	↔	↔	↔	↔	↔
U50,488H	√^*	X	↓^*	↔	↔	↓^*	↔	↔

*significant antagonism with ML-190, p ≤ 0.05

↓ = inhibit, ↑ = enhance, ↔ = no changes, √ = yes, X = no