Table 1. Demographic data for liver transplant recipients, based on APOL1 genotype of African American deceased donors.
| APOL1* renal-risk variant number in liver donors | ||||
|---|---|---|---|---|
| Variable | APOL1 = 0 (N = 247) | APOL1 = 1 (N = 300) | APOL1 = 2 (N = 92) | P-value |
| Donor age (years) | 36.3 (17.5) 37 | 37.9 (17.7) 41 | 37 (15.4) 40 | 0.64 |
| Recipient age at transplant (years) | 49.8 (16.5) 54 | 50.1 (16.4) 55 | 52.8 (14) 54 | 0.57 |
| Recipient body mass index (kg/m2) | 27.4 (6.3) 26.9 | 27.9 (6.6) 27.5 | 28.6 (5.9) 28.6 | 0.13 |
| Cold ischemia time (hours) | 6.7 (3) 6.3 | 7.1 (3.7) 6.6 | 6.9 (3.3) 6.2 | 0.46 |
| Recipient gender (male) | 170 (68.8%) | 211 (70.3%) | 64 (69.6%) | 0.93 |
| Donor gender (male) | 141 (57.1%) | 171 (57%) | 50 (54.3%) | 0.89 |
| Recipient ethnicity (African American) | 38 (15.4%) | 50 (16.7%) | 15 (16.3%) | 0.92 |
| Standard-criteria donor (Yes) | 54 (22.3%) | 78 (26.4%) | 14 (15.9%) | 0.11 |
| Non-heart-beating donor (Yes) | 5 (2%) | 3 (1%) | 1 (1.1%) | 0.57 |
| Recipient drug induction (Yes) | 141 (58.8%) | 183 (63.1%) | 65 (70.7%) | 0.13 |
| Previous transplant—liver (Yes) | 17 (6.9%) | 20 (6.7%) | 11 (12%) | 0.22 |
| Recipient previous hepatic malignancy (Yes) | 2 (0.8%) | 6 (2%) | 3 (3.3%) | 0.27 |
| Recipient HCV Status | 0.76 | |||
| Negative (<30 inhibition %) | 141 (57.1%) | 151 (50.5%) | 48 (52.7%) | |
| Unknown (30 ≤ U < 70 inhibition %) | 5 (2.0%) | 6 (2.0%) | 1 (1.1%) | |
| Positive (≥ 70 inhibition %) | 89 (36.0%) | 123 (41.1%) | 35 (38.5%) | |
| Not Done | 12 (4.9%) | 19 (6.4%) | 7 (7.7%) | |
| Recipient primary diagnosis | 0.91 | |||
| Acute hepatic necrosis | 8 (3.2%) | 151 (50.5%) | 4 (4.3%) | |
| HCV | 70 (28.3%) | 79 (26.3%) | 26 (28.3%) | |
| Alcoholic liver disease | 35 (14.2%) | 57 (19.0%) | 19 (20.7%) | |
| Cholestatic disease | 26 (10.5%) | 27 (9.0%) | 6 (6.5%) | |
| Malignancy | 23 (9.3%) | 31 (10.3%) | 9 (9.8%) | |
| Other | 85 (34.4%) | 95 (31.7%) | 28 (30.4%) | |
* APOL1 genotype defined as 0 refers to deceased donors who did not carry either G1 or G2 risk allele. APOL1 genotype defined as 1 refers to deceased donors who were heterozygous at either G1 or G2. The APOL1 genotype defined as 2 refers to deceased donors who carried 2 risk variants at either G1, G2, or were compound heterozygotes (one G1 variant and one G2 variant). Thus, APOL1 genotypes of 0, 1, or 2 indicate 0, 1, or 2 copies of G1 or G2 alleles, respectively. Data are shown as [mean (standard deviation) median], or as frequency with percentage of total, unless otherwise stated.