Table 3. Multivariate association with liver allograft failure based on deceased donor APOL1 genotype.

Recessive and additive models are in the table. Both models use the full data set of APOL1 genotyped liver donors (N = 639) in analysis and 49 events.

Variable	Hazard Ratio	95% Confidence Interval	P-value
Recessive Model
APOL1	0.80	(0.35,1.86)	0.61
Recipient gender (female)	0.79	(0.43,1.47)	0.49
Recipient ethnicity (African American)	0.59	(0.25,1.41)	0.24
Recipient age at transplant	0.98	(0.96,0.99)	0.01
Donor age	1.01	(0.98,1.04)	0.35
Expanded-criteria donor (No)	0.71	(0.26,1.90)	0.49
Previous liver transplant	1.84	(0.73,4.65)	0.20
Recipient previous hepatic malignancy	1.35	(0.15,11.87)	0.79
Recipient HCV Status (Ref = N)			0.38
Not Detected	2.33	(0.83,6.49)	0.11
Positive	1.32	(0.68,2.56)	0.41
Unknown	1.89	(0.31,11.64)	0.49
Donor source (Ref = Wake Forest)			0.45
Emory University	0.84	(0.42,1.65)	0.61
DeKAF Genomics	0.56	(0.25,1.27)	0.17
University of Alabama at Birmingham	0.53	(0.18,1.57)	0.25
Additive Model
APOL1	0.91	(0.61,1.37)	0.65
Recipient gender (female)	0.79	(0.43,1.48)	0.47
Recipient ethnicity (African American)	0.59	(0.25,1.41)	0.24
Recipient age at transplant	0.98	(0.96,0.99)	0.01
Donor age	1.01	(0.98,1.04)	0.36
Expanded-criteria donor (No)	0.69	(0.26,1.86)	0.47
Previous liver transplant	1.81	(0.72,4.58)	0.21
Recipient previous hepatic malignancy	1.35	(0.15,11.99)	0.79
Recipient HCV Status (Ref = N)			0.38
Not Detected	2.33	(0.84,6.45)	0.10
Positive	1.33	(0.69,2.57)	0.40
Unkown	1.88	(0.3,11.80)	0.50
Donor source (Ref = Wake Forest)			0.46
Emory University	0.84	(0.43,1.66)	0.62
DeKAF Genomics	0.57	(0.25,1.27)	0.17
University of Alabama at Birmingham	0.54	(0.18,1.58)	0.26