Fig 6. IL-22^-/- mice experience less DNBS-induced colitis and enhanced anti-colitic effects following infection with H. diminuta.

Wild-type (WT, gray bars) and IL-22^-/- (black bars) mice were infected with 5 H. diminuta (Hd) cysticercoids and 8 days later were given DNBS (5 mg, ir). Mice were necropsied 72 hr post-DNBS and weight loss (A) and degree of colon shortening (B) were assessed for each group. In panel (C), representative colon images from experimental groups are shown. MPO activity in the distal colon was determined and presented as granulocyte marker (D), and overall disease activity scores (DAS) are shown in (E). Data are mean ± SEM; n = 9; * and # p<0.05 compared to strain control and time-matched WT, respectively.