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. 2016 Apr 7;12(4):e1005481. doi: 10.1371/journal.ppat.1005481

Fig 8. Resistance to DNBS colitis in IL-22-/- mice requires IL-25.

Fig 8

Wild-type (WT; grey bars) and IL-22-/- (black bars) mice received 5 mg of DNBS intrarectally to induce colitis, with some IL-22-/- also receiving anti-IL-25 blocking antibody (100 μg/mouse, ip., given 10 minutes before DNBS delivery). Severity of colitis was assessed 72 hr post-DNBS by (A, B) measurement of colon length, (C) disease activity score and (D) histological damage score (data are mean ± SEM; n = 6–8; * p<0.05 compared to appropriate strain-matched control mice and # p<0.05 compared to animals given anti-IL-25 blocking antibody).