Table 2. Risks of postoperative complications according to the anesthetic method based on matched data.
| TIVA | Isoflurane | OR or HR | 95% CI | P-value | ||
|---|---|---|---|---|---|---|
| (n = 192) | (n = 662) | |||||
| Composite of in-hospital MAEs | 49 (25.5) | 139 (21) | 1.29 | 0.88–1.88 | 0.2 | |
| In-hospital death | 0 (0) | 1 (0.2) | ||||
| In-hospital myocardial infarction | 11 (5.7) | 47 (7.1) | 0.8 | 0.41–1.57 | 0.52 | |
| In-hospital revascularization | 1 (0.5) | 4 (0.6) | 0.86 | 0.09–7.79 | 0.89 | |
| In-hospital stroke | 2 (1) | 7 (1.1) | 0.99 | 0.21–4.78 | 0.99 | |
| Prolonged mechanical ventilation (>72h) | 23 (12) | 67 (10.1) | 0.84 | 0.18–3.98 | 0.83 | |
| Acute kidney injury | 5 (2.6) | 24 (3.6) | 0.7 | 0.25–1.93 | 0.49 | |
| In-hospital new arrhythmia | 38 (19.8) | 82 (12.4) | 1.72 | 1.12–2.63 | 0.01 | |
| New atrial fibrillation | 32 (16.7) | 74 (11.2) | 1.58 | 1.01–2.45 | 0.04 | |
| Postoperative ventricular arrhythmia | 6 (3.1) | 8 (1.2) | 2.55 | 0.96–6.75 | 0.06 | |
| One year MACCEs | 14 (7.3) | 58 (8.8) | 0.81 | 0.46–1.42 | 0.46 | |
| Death | 1 (0.5) | 2 (0.3) | 2.22 | 0.20–25.05 | 0.52 | |
| Myocardial infarction | 11 (6) | 44 (6.6) | 0.8 | 0.42–1.53 | 0.51 | |
| Revascularization | 1 (0.5) | 9 (1.4) | 0.39 | 0.05–3.10 | 0.37 | |
| Stroke | 2 (1) | 9 (1.4) | 0.89 | 0.19–4.18 | 0.89 | |
| Other postoperative outcomes | ||||||
| Prolonged ICU stay (>72h) | 23 (12) | 67 (10.1) | 0.83 | 0.51–1.35 | 0.45 | |
| In-hospital wound problem | 5 (2.6) | 15 (2.3) | 1.14 | 0.39–3.30 | 0.81 | |
| Bleeding-related reoperation | 4 (2) | 7 (1.1) | 1.96 | 0.57–6.68 | 0.28 | |
| Time to extubation, hr | 8 [6–12] | 8 [6–12] | 0.71* | |||
| Length of stay at ICU, hr | 34.5 [20–45.63] | 35.75 [22–48] | 0.49* | |||
| CKMBmax | 9.94 [6.79–15.65] | 10.9 [7.01–16.89] | 0.44* | |||
| Troponin Imax | 2.29 [1.33–4.73] | 2.70 [1.32–5.07] | 0.68* | |||
| NT-proBNPmax | 361.3 [155–711.9] | 346.97 [154.57–713.91] | 0.26* | |||
Data are presented as number (%) or median [interquartile range].
*P-value was analyzed with the log-transformed data.
TIVA indicates propofol-remifentanil total intravenous anesthesia; OR, odds ratio; HR, hazard ratio; CI, confidence interval; MAEs, major adverse events; MACCEs, major adverse cardiovascular and cerebral events; ICU, intensive care unit; CKMBmax, postoperative maximum creatine kinase-MB; NT-proBNPmax, postoperative maximum N-terminal pro-brain natriuretic peptide.