Table 3. Selenium status and association with bone mineral density.
| BMD mg/cm2 | SePP | Se | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Linear regression | Multivariate regression | Quartiles | Linear regression | Multivariate regression | Quartiles | |||||||
| B(SE) Unadjusted | P Unadjusted | B(SE) Adjusted | P Adjusted | Q1 Mean(SE) | Q4 Mean(SE) | B(SE) Unadjusted | P Unadjusted | B(SE) Adjusted | P Adjusted | Q1 Mean(SE) | Q4 Mean(SE) | |
| Total | 15.57(6.68) | 0.02* | 13.36 (6.09) | 0.03* | 1147.6(10.1) | 1187.6(9.9) | 0.87(0.28) | 0.001** | 0.81(0.26) | 0.001** | 1155.6(9.9) | 1195.6(9.8) |
| Femoral neck | 13.42(10.15) | 0.14 | 10.72(9.91) | 0.21 | 855.5(15.3) | 899.9(15.1) | 1.36(0.42) | 0.001** | 1.24(0.41) | 0.002** | 848.6(15.0) | 924.5(14.7) |
| Femoral trochanter | 26.35(10.23) | 0.01* | 23.80(9.52) | 0.01* | 812.7 (15.4) | 881.7(15.2) | 1.50(0.43) | <0.001*** | 1.40(0.40) | <0.001*** | 813.9(15.0) | 903.6(14.8) |
| Femoral ward | 16.22(11.30) | 0.08 | 12.55(11.14) | 0.15 | 688.6(17.1) | 736.4(16.8) | 1.38(0.47) | 0.003** | 1.25(0.47) | 0.006** | 678.4(16.7) | 760.3(16.5) |
The results (B(SE) and corresponding p-values) of the linear regression analyses of SePP and Se levels versus BMD are shown. Multivariate linear model was used to correct for TSH, FT4, age, BMI, physical performance score, smoking status, known and new onset diabetes mellitus and total number of medication use (B(SE) adjusted and corresponding adjusted p-values). Mean values for the lowest and highest Se and SePP quartiles are presented to provide extra insight into the actual effects. Abbreviations:B, Beta; BMD, bone mineral density; BMI, body mass index; FT4, free thyroxine; Se, Selenium; (SE), standard error; SePP, selenoprotein P; TSH, thyroid stimulating hormone; Q1, first quartile; Q4, fourth quartile;
*, P<0.05;
**, P<0.01;
***, P<0.001