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. 2016 Apr 7;11(4):e0153288. doi: 10.1371/journal.pone.0153288

Fig 2. Effect of DEX on IL-12 and IL-23 production in mature DCs.

Fig 2

(A), (B) and (C) showed mRNA levels of IL-12 p35, IL-12 p40 and IL-23 p19, respectively. (D) and (E) showed the protein levels of IL-12 and IL-23, respectively. “DEX” is short for dexmedetomidine, “YOH” is short for yohimbine. Immature DCs were differentiated in the absence or presence of different doses of DEX (1ng/ml, 2ng/ml and 4ng/ml) and yohimbine (4ng/ml, 8ng/ml and 16ng/ml) for 1 day before matured with TNF-α (“-”means do not add DEX or yohimbine). Grouping is consistent in these bar charts. The data were expressed as mean±SD of the results from these experiments. #: P<0.05, compared to the control group; *: P<0.05, compared to the relative DEX only group.