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. Author manuscript; available in PMC: 2017 Mar 14.
Published in final edited form as: Angew Chem Int Ed Engl. 2016 Feb 23;55(12):4097–4100. doi: 10.1002/anie.201600233

Figure 3.

Figure 3

Nanotriangle self-assembly efficiency and dissociation in the presence of ligand. Ligand binding of the IIa switch captures an elongated conformation of the RNA.[16] a) Assembly of the small triangle is not affected in the presence of a binding ligand. Assembly of the large triangle is partially prevented in the presence of a binding ligand. Single corner units of the large triangle construct, captured by the ligand in an elongated conformation, prevent triangle formation and promotes end-to-end multimerization into longer species. b) Dissociation of large triangles was observed when incubated post-assembly with a binding ligand. c) Structure of the benzimidazole ligand which binds to the IIa RNA switch element of the nanotriangles.