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. 2016 Feb 17;3:16001. doi: 10.1038/mto.2016.1

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Copyright © 2016 Official journal of the American Society of Gene & Cell Therapy

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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The IFNγ-encoded virus is not impaired in its replication kinetics and cytotoxicity. (a) Schematic representation of the VSVΔ51 and VSVΔ51-IFNγ viral backbones. (b) Replication kinetics of VSVΔ51 and VSVΔ51-IFNγ in the 4T1 and (c) CT26 tumor cell lines upon infection at a multiplicity of infection (MOI) of 0.1. The dashed line indicates the limit of detection. The graphs show virus titers obtained from duplicate samples. (d) In vitro cell viability assay of 4T1 and CT26 cells infected for 24 hours at various MOIs. Results were normalized to the average of the values obtained for the corresponding noninfected cells. Results represent values obtained from triplicate samples. There is no statistically significant difference between the viruses in b, c, and d, according to the two-way analysis of variance test.