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. 2016 Feb 17;3:16001. doi: 10.1038/mto.2016.1

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Copyright © 2016 Official journal of the American Society of Gene & Cell Therapy

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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VSVΔ51-IFNγ induces increased serum levels of various proinflammatory cytokines. (a) VSV N mRNA levels in the tumors and spleens of intratumorally-treated animals 24 and 48 hours post-treatment (single injection) were assessed by quantitative polymerase chain reaction (qPCR) (n = 3). Results are expressed as fold increase over the average obtained for VSVΔ51 at 24 hours in the tumors. (b) IL-6 and IFNγ mRNA levels in the tumors of phosphate-buffered saline (PBS) or virus-treated animals 24 and 48 hours after a single intratumoral treatment were assessed by qPCR (n = 4). Results are expressed as fold increase over the average obtained for VSVΔ51 at 24 hours in the tumors. (c) Cytometric bead array histograms showing one representative sample per group. Levels of various proinflammatory cytokines in the serum of 4T1 tumor-bearing mice treated IT with PBS or virus 24 hours after treatment were analyzed. The numbers in the legend indicate the cytokine concentration in the serum. (d) Relative concentration of each cytokine for all animals tested. The data represents a combination of two different experiments. *P < 0.1, **P < 0.01, ***P < 0.001 (unpaired one-tailed T-test).