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. 2015 Aug 27;11(10):1891–1904. doi: 10.1080/15548627.2015.1085742

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Figure 7. — A combination of a lysosome destabilizing agent and an inhibitor of ABC transporters reverted sunitinib resistance of 786-OR cells. (A) Expression of ABCB1 was detected by immunofluorescence in control (Ct) or sunitinib-treated (2.5 μmol/L) sensitive 786-O cells (786-OS) for 48 h (sun) and in resistant 786-O cells (786-OR) in the presence of sunitinib (sun). (B) Determination of the percentage of dead 786-OS and 786-OR cells after incubation for 24 h the indicated combinations of drugs (sunitinib (sun) 2.5 μmol/L; LLOM (L) 1 μmol/L; elacridar (E) 5 μmol/L). *, P < 0.05; ***, P < 0.001.