Figure 4.

MAPK14 blockade differentially affects DU145 and PC3 cell growth and survival. DU145 and PC3 cells were treated with DMSO or SB202190 for the indicated periods of time. At the end of the treatment, relative cell viability (A, D), proliferative index (using the WST-1 assay) (B, E) and cell death (C, F) were determined at the indicated time points. Statistical analysis was performed using the Student t test; *, P<0.05, which was considered statistically significant. The presented results are representative of at least 3 independent experiments.