Table 2.
Composition and functional specificity of Vps34/PIK3C3 complexes in yeast and mammals
| Yeast |
Mammals |
|||
|---|---|---|---|---|
| Complex | PtdIns3K complex I | PtdIns3K complex II | PtdIns3K-C1 | PtdIns3K-C2 |
| Core kinase | Vps34 | Vps34 | PIK3C3 | PIK3C3 |
| Regulatory subunits | Vps30 | Vps30 | BECN1 | BECN1 |
| Vps15 | Vps15 | PIK3R4 | PIK3R4 | |
| Atg38 | NRBF2 | |||
| Defining component | Atg14 | Vps38 | ATG14 | UVRAG |
| Biological function | Autophagy | Vacuole protein sorting | Autophagy | Endosomal trafficking and autophagy* |
*The role of PtdIns3K-C2 in autophagy is still controversial.