Figure 8.

Proposed mechanism for TMBIM6-induced regulation against CsA-associated autophagy process alteration and renal injury. TMBIM6 protects against CsA toxicity by activating autophagy and enhancing autophagic degradation. TMBIM6 enhances PRKAA phosphorylation, regulates MTORC1 activity and increases TFEB activity. Resultantly, lysosome biogenesis, autolysosome formation, and autophagic flux are stimulated in the presence of TMBIM6, inhibiting CsA-induced autophagosome accumulation and its linked renal injury.