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. 2015 Sep 22;11(11):2014–2032. doi: 10.1080/15548627.2015.1096485

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© 2015 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 8. — Defective VSMC autophagy accelerates atherogenesis after 10 wk of western-type diet. (A) Atg7^+/+Tagln-Cre⁺ apoe^−/− (+/+) and Atg7^F/FTagln-Cre⁺,apoe^−/− (−/−) mice (n = 16) were fed a western-type diet for 10 wk. Sections of the brachiocephalic artery were stained with H&E to quantify plaque size and percentage of necrosis. (*, P<0.05; Student t test). (B to D) Consecutive sections were immunostained for cleaved CASP3 (B), LAMP2 (C) and ACTA2 (D) to measure the percentage of apoptosis (indicated by a black arrowhead in the high-power photograph of the boxed area in the left corner of each image), percentage of macrophages and fibrous cap thickness (indicated by black arrows), respectively (*, P < 0.05; Student t test (B); ***, P < 0.001; Student t test (C); *P < 0.05; n = 10 measurements/mouse, Repeated Measure (D)). (E) Consecutive sections were stained with Sirius red to quantify total collagen. (*, P < 0.05; Student t test). *, necrotic core. Scale bar: 100 µm.