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. 2015 Sep 22;11(11):2014–2032. doi: 10.1080/15548627.2015.1096485

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© 2015 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 9. — Defective VSMC autophagy promotes formation of a thick fibrous cap and enhances total collagen deposition after 14 wk of western-type diet. (A) Atg7^+/+Tagln-Cre⁺,apoe^−/− (+/+) and Atg7^F/FTagln-Cre⁺,apoe^−/− (−/−) mice (n = 16) were fed a western-type diet for 14 wk. Sections of the brachiocephalic artery were stained with H&E to quantify plaque size and percentage of necrosis. (NS, not significant; Student t test). (B to D) Consecutive sections were immunostained for cleaved CASP3 (B), LAMP2 (C) and ACTA2 (D) to measure the percentage of apoptosis, percentage of macrophages and fibrous cap thickness (indicated by black arrows), respectively. (NS, not significant; Student t test (B,C); **, P < 0.01; n = 10 measurements/mouse, Repeated Measure (D)). (E) Consecutive sections were stained with Sirius red to quantify total collagen. (*, P < 0.05; Student t test). Scale bar: 100 µm. *, necrotic core.