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Effects of renal medullary interstitial (i.r.) infusion of inflammasome stimulator, monosodium urate (MSU) on renal blood flows in anesthetized mice. YVAD: caspase-1 inhibitor Ac-YVAD-CMK (1mg/Kg/ min, 30 mins). MAP: mean arterial blood pressure; CBF: renal cortical blood flow; MBF: renal medullary blood flow. C: control period, P: post period. Values are arithmetic means ± SEM (n=6 mice per group), * P<0.05 vs. control periods; # P<0.05 vs. vehicle group.
