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Activation of renal medullary inflammasomes by i.r. MSU. (A) Western blot analysis showing MSU-induced increase in cleaved caspase-1 level in the medulla in the absence and presence of Ac-YVAD-CMK. (B) MSU-induced increase in caspase-1 activity and IL-1β production in the renal medulla. n=6 mice per group. Ctrl: control, Vehl: vehicle, YVAD: Ac-YVAD-CMK. Values are arithmetic means ± SEM (n=6 mice per group), * P<0.05 vs. control periods; # P<0.05 vs. vehicle group.
