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No activation of renal medullary inflammasomes by i.r MSU in Asc KO mice. (A) Western blot analysis showing MSU–induced increase in cleaved caspase-1 levels in WT mice, but not in ASC KO mice. (B) Effect of ASC gene deletion on caspase-1 activity and IL-1β production induced by MSU in the renal medulla. Values are arithmetic means ± SEM (n=6 mice per group), * P<0.05 vs. control periods; # P<0.05 vs WT mice with i. r. MSU. WT: C57BL/6J mice; Asc KO: Asc gene knockout mice.
