Table 2.
A-to-I editing of mammalian microRNAs (miRNAs)
| miRNA* | Position‡ | Editing levels (%)§ | ADAR responsible | Refs | |
|---|---|---|---|---|---|
| Human | Mouse | ||||
| let-7g | +7 | 10 | 0 | – | 21 |
| + 10 | 30 | 20 | ADAR2 | ||
| let-7-2-5P | +10 | 10 | 0 | – | 21 |
| miR-27a-5P | −6 | 30 | 0 | – | 21 |
| +1 | 50 | 20 | ADAR2 | ||
| +7 | 10 | 0 | – | ||
| miR-33a-5P | +10 | 30 | 0 | – | 21 |
| miR-34b-5P | +11 | – | 40 | – | 124 |
| miR-99a-5P | +1 | 20 | 20 | ADAR2 | 21 |
| miR-99b-3P | −1 | 10 | 10 | ADAR1 | 21 |
| +3 | 50 | 10 | ADAR1 | ||
| miR-122-5p | −7 | 30 | – | ADAR2 | 145 |
| miR-142-5P | +4 | – | 5 | ADAR1 | 24 |
| +5 | – | 5 | ADAR1 | ||
| miR-142-3P | +4 (+40)∥ | – | 10 | ADAR1, ADAR2 | 24 |
| miR-151-3P | −1 | – | 10 | ADAR1 | 22 |
| +3 | 40 | 30 | ADAR1 | ||
| miR-153-1-3P | +7 | 10 | 0 | – | 21 |
| miR-153-2-3P | +7 | 30 | 0 | – | 21 |
| miR-197-3P | −34 | 30 | – | – | 21 |
| miR-203-3P | +21 | 60 | – | ADAR2 | 21 |
| miR-214-3p | +6 | 10 | – | ADAR2 | 145 |
| miR-376a-1-5P | +3 (+4)∥ | 50 | – | ADAR2 | 23 |
| miR-376a-1-3P | +6 (+44)∥ | 40 | 0 | ADAR1 | 23 |
| miR-376a-2-5P | +4 | 90 | 50 | ADAR2 | 23 |
| miR-376a-2-3P | +6 (+44)∥ | 100 | 0 | ADAR1 | 23 |
| miR-376b-3p | +6 (+44)∥ | 95 | 50 | ADAR1 | 23 |
| miR-379-5P | +5 | 60 | 20 | ADAR2 | 21 |
| miR-381-3P | +4 | 6 | 13 | – | 115, 116 |
| miR-411-5P | +5 | 80 | 60 | ADAR1 | 21 |
| miR-423 + 5P | −4 | 40 | 20 | ADAR1 | 21 |
| miR-497-5P | +2 | 6 | 10 | – | 115, 116 |
| miR-532-5P | +15 | 10 | 0 | – | 21 |
| miR-589-3P | +6 | 70 | – | – | 115 |
| miR-607-3P | +6 | 70 | – | – | 21 |
| +17 | 80 | – | – | ||
| +20 | 80 | – | – | ||
| miR-652-5P | −10 | 40 | 0 | – | 21 |
| miR-3099-3P | +7 | – | 80 | – | 124 |
ADAR, adenosine deaminase acting on RNA.
*
Only editing sites verified by sequencing of specific primary mRNAs (pri-miRNAs) or detected independently more than once by deep sequencing of mature miRNAs are listed.
‡
The 5′ end of the human mature miRNA sequence registered at the miRBase database is counted as +1.
§
Editing levels indicate fractions of edited miRNAs over edited and unedited miRNAs. The highest editing level reported either in total brain tissue, in sub-regions of the brain or in cultured cells is presented.
∥
Alternative numbering used in certain references is indicated in parentheses.